analysis of the sequence from a Holstein calf afflicted with leukocyte adhesion deficiency (LAD), two point mutations were detected within the gene encoding bovine CD18: one mutation replaced adenine at the nucleotide 383 with guanine, and the other mutation replaced the cytosine at the nucleotide 775 with thymine.
从一患白细胞粘附缺陷症(LAD)的黑白花奶牛犊的核苷酸顺序分析中,发现牛的抗原分子分化群18(CD18)的基因密码有二处发生了点突变;一处在第383核苷酸上,在此处原有的腺瞟吟已被鸟嘌呤取代;另一处在第775核苷酸上,在此处原有的胞嘧啶被胸腺嘧啶取代了。
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